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Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis

Title
Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis
Authors
Park Y.J.Lee J.Y.Yeom H.R.Kim K.H.Lee S.C.Shim I.K.Chung C.P.Lee S.J.
Ewha Authors
이승진심인경
SCOPUS Author ID
이승진scopus
Issue Date
2005
Journal Title
Biotechnology Letters
ISSN
0141-5492JCR Link
Citation
vol. 27, no. 22, pp. 1761 - 1766
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Injectable polysaccharide microcapsules holding minocycline were fabricated from alginate and chitosan for the treatment of periodontitis. The microcapsules were examined for the release and degradation of minocycline, as well as antimicrobial activity. The microcapsules were biodegradable and released minocycline between 10 and 1000 μg ml-1, which was higher than the usual therapeutic concentration (1-5 μg ml-1), for up to 7 days. These microcapsules showed a statistically significant suppression of pathogenic bacteria, such as Prevotella intermedia causing periodontitis. The microcapsules are thus potentially useful for drug delivery for the treatment of periodontitis. © Springer 2005.
DOI
10.1007/s10529-005-3550-7
Appears in Collections:
약학대학 > 약학과 > Journal papers
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