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Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells

Title
Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells
Authors
Kang K.A.Lee K.H.Chae S.Zhang R.Jung M.S.Lee Y.Kim S.Y.Kim H.S.Joo H.G.Park J.W.Ham Y.M.Lee N.H.Hyun J.W.
Ewha Authors
김희선
SCOPUS Author ID
김희선scopus
Issue Date
2005
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 579, no. 28, pp. 6295 - 6304
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We have investigated the cytoprotective effect of eckol, which was isolated from Ecklonia cava, against oxidative stress induced cell damage in Chinese hamster lung fibroblast (V79-4) cells. Eckol was found to scavenge 1,1-diphenyl-2-picrylhydrazyl radical, hydrogen peroxide (H2O 2), hydroxy radical, intracellular reactive oxygen species (ROS), and thus prevented lipid peroxidation. As a result, eckol reduced H 2O2 induced cell death in V79-4 cells. In addition, eckol inhibited cell damage induced by serum starvation and radiation by scavenging ROS. Eckol was found to increase the activity of catalase and its protein expression. Further, molecular mechanistic study revealed that eckol increased phosphorylation of extracellular signal-regulated kinase and activity of nuclear factor κ B. Taken together, the results suggest that eckol protects V79-4 cells against oxidative damage by enhancing the cellular antioxidant activity and modulating cellular signal pathway. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reseved.
DOI
10.1016/j.febslet.2005.10.008
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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