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Aggressive vestibular schwannomas showing postoperative rapid growth - Their association with decreased p27 expression

Title
Aggressive vestibular schwannomas showing postoperative rapid growth - Their association with decreased p27 expression
Authors
Seol H.J.Jung H.-W.Park S.-H.Hwang S.-K.Kim D.G.Paek S.H.Chung Y.-S.Lee C.S.
Ewha Authors
황승균
SCOPUS Author ID
황승균scopus
Issue Date
2005
Journal Title
Journal of Neuro-Oncology
ISSN
0167-594XJCR Link
Citation
vol. 75, no. 2, pp. 203 - 207
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Vestibular schwannomas (VSs) are relatively slow growing tumors. However, some rapidly regrow or recur after surgical resection. The objective of this study was to identify those molecular characteristics predicting rapid recurrence after surgical resection. Immunohistochemically determined expressions of several cell cycle regulators and apoptosis-associated proteins in 12 cases of aggressive VS (AVS) and in 15 control cases of usual VS (UVS) cases were compared. The expressions of p53 and Bax (pro-apoptotic protein), Bcl-2 (anti-apoptotic protein), Fas, and Fas-L (apoptotic death receptor and ligand), caspase 3 (apoptotic effector caspase proteins), and p27 and p21 (cyclin-dependent kinase inhibitors) were analyzed using tissue array blocks. Loss of p27 expression was observed in 8 of 12 AVS cases (67%) and in 3 UVS cases (20%); p21 was expressed in all cases. Loss of Bax was observed in 3 AVS and 3 UVS cases. The anti-apoptotic protein, Bcl-2, was expressed in 9 AVS (75%) and 11 UVS (73%), and p53, Fas-L, and caspase 3 were negative and Fas was positive in all AVS and UVS cases. Of these, only the loss of p27 was statistically significant (P = 0.02). The loss of p27 in AVS may explain the unusually high proliferative potential of AVS versus UVS, and p27 may be a predictor of VS aggressiveness. The expressions of other apoptosis associated proteins were not significantly different in the two groups. This may be the first report to identify a molecular entity associated with aggressive VS. However, further studies are required. © Springer 2005.
DOI
10.1007/s11060-005-2886-0
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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