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Cytoprotective effect of tectorigenin, a metabolite formed by transformation of tectoridin by intestinal microflora, on oxidative stress induced by hydrogen peroxide

Title
Cytoprotective effect of tectorigenin, a metabolite formed by transformation of tectoridin by intestinal microflora, on oxidative stress induced by hydrogen peroxide
Authors
Kang K.A.Lee K.H.Chae S.Zhang R.Jung M.S.Kim S.Y.Kim H.S.Kim D.H.Hyun J.W.
Ewha Authors
김희선
SCOPUS Author ID
김희선scopus
Issue Date
2005
Journal Title
European Journal of Pharmacology
ISSN
0014-2999JCR Link
Citation
vol. 519, no. 41276, pp. 16 - 23
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In the present study, the antioxidative properties of tectorigenin, a metabolite formed by transformation of tectoridin by intestinal microflora, were investigated. Tectorigenin was found to scavenge intracellular reactive oxygen species, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and thus prevented lipid peroxidation. The radical scavenging activity of tectorigenin protected the viability of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O2) via activation of extracellular signal regulated kinase (ERK) pathway. Furthermore, tectorigenin reduced the apoptotic cells formation and cell cycle arrest at G2/M phase induced by H2O2. Tectorigenin increased the activities of cellular antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase, and also increased their protein level. Taken together, these findings suggest that tectorigenin protected V79-4 cells against H 2O2 damage, by enhancing the antioxidative activity and by activating ERK pathway. © 2005 Elsevier B.V. All rights reserved.
DOI
10.1016/j.ejphar.2005.06.043
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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