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Synthesis and antifungal activity of 2/3-arylthio- and 2,3-bis(arylthio)-5- hydroxy-/5-methoxy-1,4-naphthoquinones

Title
Synthesis and antifungal activity of 2/3-arylthio- and 2,3-bis(arylthio)-5- hydroxy-/5-methoxy-1,4-naphthoquinones
Authors
Ryu C.-K.Shim J.-Y.Mi J.C.Ik H.C.Han J.-Y.Jung O.-J.Jung Y.L.Seong H.J.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2005
Journal Title
European Journal of Medicinal Chemistry
ISSN
0223-5234JCR Link
Citation
vol. 40, no. 5, pp. 438 - 444
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
2/3-Arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4- naphthoquinones 5-9 were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. The synthesized compounds 5-9 generally showed good activities against Candida albicans and C. tropicalis. The results suggest that the 1,4-naphthoquinones 5-9 would be potent antifungal agents. © 2005 Elsevier SAS. All rights reserved.
DOI
10.1016/j.ejmech.2004.12.004
Appears in Collections:
약학대학 > 약학과 > Journal papers
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