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Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer

Title
Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer
Authors
Choi J.-Y.Lee K.-M.Park S.K.Noh D.-Y.Ahn S.-H.Chung H.-W.Han W.Kim J.S.Shin S.G.Jang I.-J.Yoo K.-Y.Hirvonen A.Kang D.
Ewha Authors
정혜원
SCOPUS Author ID
정혜원scopus
Issue Date
2005
Journal Title
Cancer Epidemiology Biomarkers and Prevention
ISSN
1055-9965JCR Link
Citation
vol. 14, no. 5, pp. 1090 - 1095
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We examined whether common single nucleotide polymorphisms (SNP) in SULT1A1 (c.779G>A, *14A>G, and *85C>T) and SULT1E1 (IVS1-447C>A, IVS4-1653T>C, and *959G>A) genes influenced the risk and survival of breast cancer. Our study population consisted of 989 histologically confirmed sporadic breast cancer patients and 1,054 controls without history of cancer recruited from three teaching hospitals in Seoul. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by logistic regression model. In the survival analysis for 529 breast cancer patients with completed treatments, the hazard ratios (HR) were calculated with Cox proportional hazard model. Women with the SULT1E1 *959 GA/AA genotype had a moderately decreased breast cancer risk compared with those with the GG genotypes (OR, 0.8; 95% CI, 0.70-1.00). When the haplotypes were considered, the homozygous *959 AA genotype together with the IVS4-1653 T>C base change (CTA-CCA haplotype) was associated with halved breast cancer risk (OR, 0.5; 95% CI, 0.24-0.88) compared with the wild type CTG-CTG haplotype. No other significant overall association was observed between the SULT1A1 and SULT1E1 SNPs nor haplotypes and breast cancer risk. When stratified by survival, patients with the SULT1E1 IVS4-1653 TC/CC genotypes showed a >3-fold risk of recurrence (HR, 3.2; 95% CI, 1.39-7.48) compared with those with the TT genotype. Moreover, when the haplotypes were considered, the SULT1E1 *959 G>A base change together with the IVS4-1653 T>C base change (CTG-CCA haplotype) was associated with a >4-fold risk of breast cancer (OR, 4.2; 95% CI, 1.15-15.15). These findings suggest that genetic polymorphisms of SULT1E1 are associated with increased risk and a disease free survival of breast cancer in Korean women. Copyright © 2005 American Association for Cancer Research.
DOI
10.1158/1055-9965.EPI-04-0688
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의학전문대학원 > 의학과 > Journal papers
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