Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정혜원 | * |
dc.date.accessioned | 2016-08-28T11:08:50Z | - |
dc.date.available | 2016-08-28T11:08:50Z | - |
dc.date.issued | 2005 | * |
dc.identifier.issn | 1055-9965 | * |
dc.identifier.other | OAK-2672 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219548 | - |
dc.description.abstract | To evaluate the role of genetic polymorphisms of ataxia telangiectasia mutated (ATM) in the etiology of breast cancer, a hospital-based case-control study was conducted in Korea. Nine-hundred ninety-six histologically confirmed incident breast cancer cases and 1,181 cancer-free controls were recruited in Seoul between 1995 and 2003. Genotypes of the ATM polymorphisms-5144A>T, IVS21+1049T>C, IVS33-55T>C, IVS34+60G>A, and 3393T>G were determined by the 5′-nuclease assay. Individual haplotypes were estimated from genotype data by a Bayesian method. Five ATM alleles were found to be in strong linkage disequilibrium (D′ > 0.82; P < 0.001). Haplotype frequencies were significantly different between cases and controls (χ2 test, P < 0.001). The ATM IVS21+1049 TC or CC, IVS34+60 GA or AA, and 3393 TG or GG genotypes were associated with increased breast cancer risk, particularly in premenopausal women [odds ratios (OR), 1.51; 95% confidence interval (CI), 1.11-2.05; OR, 1.42; 95% CI, 1.08-1.88; and OR, 1.37; 95% CI, 1.04-1.80, respectively]. Compared with diploid of TCCAG:TCCAG, the most common haplotype, the ATTGT:ATTGT was associated with decreased risk of breast cancer with borderline significance (OR, 0.77; 95% CI, 0.58-1.04) and TCCAG:ATCGT and ATTGT:ACCAG were associated with increased breast cancer risk (OR, 2.30; 95% CI, 1.18-4.48 and OR, 2.43; 95% CI, 1.1.07-5.52, respectively) after adjusting for age, education, age at first full-term pregnancy, parity, family history of breast cancer, alcohol consumption, and smoking. As the number of ATTGT haplotype decreased, the risk of breast cancer increased (P for trend <0.01). Our results thus suggest that genetic polymorphisms of ATM play an important role in the development of breast cancer in Korean women. Copyright © 2005 American Association for Cancer Research. | * |
dc.language | English | * |
dc.title | Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 14 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 821 | * |
dc.relation.lastpage | 825 | * |
dc.relation.journaltitle | Cancer Epidemiology Biomarkers and Prevention | * |
dc.identifier.doi | 10.1158/1055-9965.EPI-04-0330 | * |
dc.identifier.wosid | WOS:000228351300011 | * |
dc.identifier.scopusid | 2-s2.0-20144387375 | * |
dc.author.google | Lee K.-M. | * |
dc.author.google | Choi J.-Y. | * |
dc.author.google | Sue K.P. | * |
dc.author.google | Chung H.-W. | * |
dc.author.google | Ahn B. | * |
dc.author.google | Yoo K.-Y. | * |
dc.author.google | Han W. | * |
dc.author.google | Noh D.-Y. | * |
dc.author.google | Ahn S.-H. | * |
dc.author.google | Kim H. | * |
dc.author.google | Wei Q. | * |
dc.author.google | Kang D. | * |
dc.contributor.scopusid | 정혜원(56499737200) | * |
dc.date.modifydate | 20240415131357 | * |