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Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

Title
Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins
Authors
Rhee S.G.Kang S.W.Jeong W.Chang T.-S.Yang K.-S.Woo H.A.
Ewha Authors
이서구강상원정우진창동신우현애
SCOPUS Author ID
이서구scopusscopus; 강상원scopus; 정우진scopus; 창동신scopus; 우현애scopus
Issue Date
2005
Journal Title
Current Opinion in Cell Biology
ISSN
0955-0674JCR Link
Citation
vol. 17, no. 2, pp. 183 - 189
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Hydrogen peroxide (H2O2) accumulates transiently in various cell types stimulated with peptide growth factors and participates in receptor signaling by oxidizing the essential cysteine residues of protein tyrosine phosphatases and the lipid phosphatase PTEN. The reversible inactivation of these phosphatases by H2O2 is likely required to prevent futile cycles of phosphorylation-dephosphorylation of proteins and phosphoinositides. The accumulation of H2O2 is possible even in the presence of large amounts of the antioxidant enzymes peroxiredoxin I and II in the cytosol, probably because of a built-in mechanism of peroxiredoxin inactivation that is mediated by H2O2 and reversed by an ATP-dependent reduction reaction catalyzed by sulfiredoxin. © 2005 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.ceb.2005.02.004
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일반대학원 > 생명·약학부 > Journal papers
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