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Oxidative stress in pregnant women and birth weight reduction

Title
Oxidative stress in pregnant women and birth weight reduction
Authors
Kim Y.-J.Hong Y.-C.Lee K.-H.Park H.J.Park E.A.Moon H.-S.Ha E.-H.
Ewha Authors
하은희박은애김영주문혜성
SCOPUS Author ID
하은희scopus; 박은애scopus; 김영주scopus; 문혜성scopus
Issue Date
2005
Journal Title
Reproductive Toxicology
ISSN
0890-6238JCR Link
Citation
vol. 19, no. 4, pp. 487 - 492
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The purpose of this study is to evaluate the role of maternal oxidative stress in lowering neonatal birth weight. Women (N = 261) with singleton pregnancy were analyzed for biomarker levels of oxidative stress after recruitment at the time of hospitalization for delivery in Korea between 2000 and 2001. Among the neonates, 247 births were full-term infants and 14 births were pre-term infants. Biomarkers measured for oxidative stress were maternal urinary 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA). The women with pre-term infants had higher concentrations of urinary 8-OH-dG and MDA than those with full-term babies. The concentrations of maternal urinary 8-OH-dG and MDA were inversely associated with birth weight of full-term deliveries after adjusting for potential confounders including maternal age, body mass index, dietary intake, alcohol consumption, smoking exposure, occupational status, and neonatal sex (P < 0.05). This study demonstrates that increase of 8-OH-dG and MDA concentrations in urine of pregnant women were associated with reduced birth weight in full-term deliveries. © 2005 Published by Elsevier Inc.
DOI
10.1016/j.reprotox.2004.10.007
Appears in Collections:
의과대학 > 의학과 > Journal papers
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