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Transplant graft vasculopathy: An emerging target for prevention and treatment of renal allograft dysfunction

Title
Transplant graft vasculopathy: An emerging target for prevention and treatment of renal allograft dysfunction
Authors
Kang D.-H.Kang S.-W.Jeong H.J.Kim Y.S.Yang C.W.Johnson R.J.
Ewha Authors
강덕희
SCOPUS Author ID
강덕희scopus
Issue Date
2004
Journal Title
Yonsei Medical Journal
ISSN
0513-5796JCR Link
Citation
vol. 45, no. 6, pp. 1053 - 1058
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Maintenance of healthy endothelium is essential to vascular homeostasis, and preservation of endothelial cell function is critical for transplant allograft function. Damage of microvascular endothelial cells is now regarded as a characteristic feature of acute vascular rejection and chronic allograft nephropathy, which is an important predictor of graft loss and is often associated with transplant vasculopathy. In this review, we will discuss the role of microvascular endothelium, in renal allograft dysfunction, particularly as it relates to markers of endothelial dysfunction and endothelial repair mechanisms. We also discuss the potential for therapies targeting endothelial dysfunction and transplant graft vasculopathy.
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의과대학 > 의학과 > Journal papers
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