A new cytotoxic phenylbutenoid dimer from the rhizomes of Zingiber cassumunar

Abstract

A new phenylbutenoid dimer, (±)-trans-3-(4-hydroxy-3-methoxyphenyl)- 4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (±)-trans-3-(3, 4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3- diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including ID and 2D NMR experiments.