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Suppressive effect of inducible nitric oxide synthase (iNOS) expression by the methanol extract of Actinodaphne lancifolia

Title
Suppressive effect of inducible nitric oxide synthase (iNOS) expression by the methanol extract of Actinodaphne lancifolia
Authors
Kim Y.Min H.-Y.Park H.-J.Lee E.-J.Park E.-J.Hwang H.-J.Jin C.Lee Y.S.Lee S.K.
Ewha Authors
이상국
Issue Date
2004
Journal Title
Phytotherapy Research
ISSN
0951-418XJCR Link
Citation
vol. 18, no. 10, pp. 853 - 856
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) has played a crucial role in various pathophysiological processes including inflammation and carcinogenesis. Therefore, the inhibitors of NO synthesis or iNOS gene expression have been considered as potential anti-inflammatory and cancer chemopreventive agents. In our continuous search for iNOS inhibitors from natural products we have evaluated indigenous Korean plant extracts using an assay for inhibition of nitric oxide formation on lipopolysaccharide (LPS)-activated mouse macrophage RAW 264.7 cells. As a result, the methanolic stem extract of Actinodaphne lancifolia showed an inhibitory activity of NO production in a dose-dependent manner (IC50 = 2.5 μg/ml). Additional study demonstrated that the extract of Actinodaphne lancifolia significantly suppressed the iNOS protein and gene expression in a dose-dependent manner. These results suggest that Actinodaphne lancifolia could be a potential candidate for developing an iNOS inhibitor from natural products. Further elucidation of active principles for development of new cancer chemopreventive and/or anti-inflammatory agents could be warranted. Copyright © 2004 John Wiley & Sons, Ltd.
DOI
10.1002/ptr.1558
Appears in Collections:
약학대학 > 약학과 > Journal papers
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