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Prevention of primary nonfunction after canine liver allotransplantation: The effect of gadolinium chloride

Title
Prevention of primary nonfunction after canine liver allotransplantation: The effect of gadolinium chloride
Authors
Chung K.Y.Jeong G.Y.Choi K.B.Sung S.H.Kim Y.S.
Ewha Authors
최규복성순희정구용김이석
SCOPUS Author ID
최규복scopus; 성순희scopus; 정구용scopus; 김이석scopus
Issue Date
2004
Journal Title
Transplantation Proceedings
ISSN
0041-1345JCR Link
Citation
vol. 36, no. 7, pp. 1928 - 1930
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Effective suppression of Kupffer cell function is believed to contribute to the prevention of preservation/reperfusion injury. In this study, effect of gadolinium, a synthetic Kupffer cell suppressant, on the reperfusion injury was examined using a canine partial liver transplantation model. About a 70% partial liver segment was harvested and reimplanted in a mongrel recipient dog weighing 20 to 25 kg. Gadolinium chloride (10 mg/kg) was infused via the cephalic vein 24 hours before harvest of the partial liver (gadolinium group, n = 5). Serum aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and morphologic grading of graft were compared with those of a control group (n = 5). Statistical analysis was done with an independent t-test. Average total ischemic time was 4 hours and 27 minutes. At 1 hour after reperfusion, there were no significant differences in AST, ALP, or LDH levels, or pathologic scores. At 48 hours after reperfusion, AST (P =. 03) and LDH (P =. 05) levels were significantly lower in the gadolinium group. Kupffer cell blockade using gadolinium chloride may be effective to reduce ischemia reperfusion injury, but the effect is not evident at an early stage of reperfusion.
DOI
10.1016/j.transproceed.2004.09.006
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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