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Development of modified stokes expression to model the behavior of expanded beds containing polydisperse resins for protein adsorption

Title
Development of modified stokes expression to model the behavior of expanded beds containing polydisperse resins for protein adsorption
Authors
Chae Y.R.Yoon Y.J.Ryu K.G.
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2004
Journal Title
Korean Journal of Chemical Engineering
ISSN
0256-1115JCR Link
Citation
vol. 21, no. 5, pp. 999 - 1002
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Expanded bed behavior was modeled by using the Richardson-Zaki correlation between the superficial velocity of the teed stream and the void fraction of the bed. A polydisperse material, Chelating excellose® (70-210 μm in diameter, 1.21 g/cm3 in density), which has Ni2+ ions for the selective binding of histidine-tagged proteins, was used as the resin. A method to modify the Stokes expression to express the terminal settling velocity of the resins by introducing two empirical parameters, the effective diameter of the resins and an exponent for (pp-p)/μ term, was developed. Combined use of the Richardson-Zaki correlation and the modified Stokes expression was successful in modeling the bed expansion by incorporating physical properties of feed streams and the resins.
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자연과학대학 > 화학·나노과학전공 > Journal papers
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