NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
약학대학
약학과
Journal papers
View : 463 Download: 0
Recent advances in 4′-thionucleosides as potential antiviral and antitumor agents
Title
Recent advances in 4′-thionucleosides as potential antiviral and antitumor agents
Authors
Gunaga P.
;
Moon H.R.
;
Choi W.J.
;
Shin D.H.
;
Park J.G.
;
Jeong L.S.
Ewha Authors
정낙신
SCOPUS Author ID
정낙신
Issue Date
2004
Journal Title
Current Medicinal Chemistry
ISSN
0929-8673
Citation
Current Medicinal Chemistry vol. 11, no. 19, pp. 2585 - 2637
Indexed
SCI; SCIE; SCOPUS
Document Type
Review
Abstract
The classical 4′-oxonucleoside analogs exhibit interesting biological activities such as antibiotic, antiviral and antitumor, which are believed to be the result of inhibition of the viral or cellular DNA or RNA polymerase after being converted to their corresponding 5′-triphosphates. However, the activity of 4′-oxonucleosides were limited by their susceptibility to degradation by nucleoside phosphorylases or acid hydrolysis. This aspect called for the chemical modification of the carbohydrate portion. This compulsion led to two kinds of strategies; (1) replacement of the 4′-oxygen by the methylene group - carbocyclic nucleosides; (2) replacement of the 4′-oxygen by sulphur-4′-thionucleosides. This group has also conferred the resistance to the nucleoside cleavage. Although, there were some pioneering work on 4′-thionucleosides in 1960s and 1970s, the interest in this group of compounds was rekindled by the antiviral activities of 2′-deoxy-4′-thionucleosides reported independently by Secrist et al. and Walker et al. Subsequent contributions by the other authors, enhanced its standing as an important class of antiviral agents. Following is a reasonably exhaustive account of this class of compounds reported after 1990. © 2004 Bentham Science Publishers Ltd.
Appears in Collections:
약학대학
>
약학과
>
Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject