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Age-related changes in erythropoietin immunoreactivity in the cerebral cortex and hippocampus of rats

Title
Age-related changes in erythropoietin immunoreactivity in the cerebral cortex and hippocampus of rats
Authors
Chung Y.H.Kim S.I.Joo K.M.Kim Y.S.Lee W.B.Yun K.W.Cha C.I.
Ewha Authors
연규월김수인
SCOPUS Author ID
연규월scopus; 김수인scopus
Issue Date
2004
Journal Title
Brain Research
ISSN
0006-8993JCR Link
Citation
vol. 1018, no. 1, pp. 141 - 146
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Although oxidative stress may influence the fluid properties of blood, resulting in a potential decrement in blood flow and oxygen delivery to the brain during aging, very little is known about age-related changes in Epo expression. Therefore, we examined age-related changes in Epo expression in the cerebral cortex and hippocampus with an immunohistochemical technique. In aged rats, there was a significant decrease in Epo immunoreactivity in the pyramidal cells in the cortical regions. In the hippocampus of adult rats, a distinct immunoreactivity pattern was observed in the CA1-3 areas and dentate gyrus. In aged hippocampus, Epo immunoreactivity was significantly deceased in the pyramidal layer of CA1 regions, and the granule cell layer of dentate gyrus. It was noted that there was distinct pattern of Epo immunoreactivity in the pyramidal layer of CA2-CA3 region of aged rats. Epo immunoreactivity was relatively strong, but was observed only in the periphery of the cytoplasm. The first demonstration of age-related decreases in Epo expression in the cerebral cortex and hippocampus may provide useful data for investigating the pathogenesis of age-related neurodegenerative diseases, suggesting that age-related decreases in Epo may contribute to degenerative events following age-related decreases in brain flow and oxygen supply. © 2004 Elsevier B.V. All rights reserved.
DOI
10.1016/j.brainres.2004.05.078
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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