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Iron enhances NGF-induced neurite outgrowth in PC12 cells

Title
Iron enhances NGF-induced neurite outgrowth in PC12 cells
Authors
Yoo Y.-E.Hong J.-H.Hur K.C.Oh E.-S.Chung J.-M.
Ewha Authors
허규정정준모오억수
SCOPUS Author ID
허규정scopus; 정준모scopus; 오억수scopus
Issue Date
2004
Journal Title
Molecules and Cells
ISSN
1016-8478JCR Link
Citation
vol. 17, no. 2, pp. 340 - 346
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Rat pheochromocytoma 12 (PC12) cells undergo neuronal differentiation in response to nerve growth factor (NGF). NGF-induced differentiation involves a number of protein kinases, including extracellular signal-regulated kinase (ERK). We studied the effect of iron on neuronal differentiation, using as model the neurite outgrowth of PC12 cells triggered by NGF when the cells are plated on collagen-coated dishes in medium containing 1% serum. The addition of iron enhanced NGF-mediated cell adhesion, spreading and neurite outgrowth. The differentiation-promoting effect of iron seems to depend on intracellular iron, since nitrilotriacetic acid (an efficient iron-uptake mediator) enhanced the response to iron. In agreement with this, intracellular, but not extracellular, iron enhanced NGF-induced neurite outgrowth in pre-spread PC12 cells, and this was correlated with increased ERK activity. Taken together, these data suggest that intracellular iron promotes NGF-stimulated differentiation of PC12 cells by increasing ERK activity. ©KSMCB 2004.
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일반대학원 > 바이오융합과학과 > Journal papers
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