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Presence of human mycoplasma DNA in gastric tissue samples from Korean chronic gastritis patients

Title
Presence of human mycoplasma DNA in gastric tissue samples from Korean chronic gastritis patients
Authors
Kwon H.-J.Kang J.-O.Cho S.-H.Kang H.-B.Kang K.-A.Kim J.-K.Kang Y.-S.Song B.-C.Kang H.-W.Shim M.-J.Kim H.-S.Kim Y.-B.Hahm K.-B.Kim B.-J.Kook M.-C.Chung M.-H.Hyun J.-W.
Ewha Authors
김희선
SCOPUS Author ID
김희선scopus
Issue Date
2004
Journal Title
Cancer Science
ISSN
1347-9032JCR Link
Citation
vol. 95, no. 4, pp. 311 - 315
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We aimed to determine whether mycoplasmas are present in Korean chronic gastritis, and to understand their roles in gastric cancer tumorigenesis, because mycoplasmas resemble Helicobacter pylori in terms of ammonia production and induction of inflammatory cytokines in immune and non-immune cells. The presence and identity of mycoplasmas were assessed by semi-nested PCR and sequencing, and the results were compared with pathologic data. Fifty-six samples collected from Korean chronic gastritis patients were used for this study. Twenty-three (41.1%) were positive for mycoplasmas. Eighteen sequenced samples contained a single human mycoplasma or two mycoplasmas, which were identified as Mycoplasma faucium (13/18), M. fermentans (3/18), M. orale (1/18), M. salivarium (2/18), and M. spermatophilum (1/ 18). Mycoplasma-infected chronic gastritis samples showed significantly more severe neutrophil infiltration than non-infected samples (P=0.0135). Mycoplasma profiles in the oral cavity (M. salivarium is major) and stomach were different, and the presence of significant proinflammatory responses in mycoplasma-positive patients suggests that the mycoplasmas are not simply contaminants. Further studies are required to understand whether mycoplasmas play a role in gastric tumorigenesis.
DOI
10.1111/j.1349-7006.2004.tb03208.x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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