Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최규복 | * |
dc.contributor.author | 한기환 | * |
dc.date.accessioned | 2016-08-28T11:08:39Z | - |
dc.date.available | 2016-08-28T11:08:39Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 0250-8095 | * |
dc.identifier.other | OAK-2109 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219419 | - |
dc.description.abstract | Background: Apoptosis plays an important role in the morphogenesis of the renal papilla. During kidney development, ATL is derived from the TAL in the inner medulla by apoptotic deletion of a fraction of TAL cells and the transformation of the remaining TAL cells. EGF is an important regulator of apoptosis in the kidney. Hypothesis: Exogenously administered EGF in postnatal rat affects renal papilla growth with cell proliferation and apoptosis in the loop of Henle. Methods: Rat pups received subcutaneous injections of EGF (0.3 μg/g body weight) or saline four times a day from after birth. Rats were sacrificed and the kidneys were preserved for immunohistochemistry on day 4 and day 7. The TAL was identified with antibody directed against Na-K-ATPase or BSC1, and type A intercalated cells were identified with antibody to anion exchanger 1 (AE1). Apoptosis was detected with TUNEL method, and cell proliferation with immunostaining for PCNA. Results - Primary and Secondary: EGF treatment resulted in the following: (1) reduced kidney weight; (2) shortened length of renal papilla; (3) delayed transformation of the cuboidal epithelium into the squamous epithelium of the ATL; (4) delayed elimination of type A intercalated cells in the medullary collecting duct; (5) decreased both apoptotic index and PCNA-positive cells in the TAL and the collecting duct of the renal medulla. Conclusion: These findings suggest that exogenous EGF delays the development of loop of Henle in the renal papilla by reducing both apoptosis and cell proliferation. Copyright © 2004 S. Karger AG, Basel. | * |
dc.language | English | * |
dc.title | Effect of epidermal growth factor on the developing rat renal papilla | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 24 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 212 | * |
dc.relation.lastpage | 220 | * |
dc.relation.journaltitle | American Journal of Nephrology | * |
dc.identifier.doi | 10.1159/000077275 | * |
dc.identifier.wosid | WOS:000220650600005 | * |
dc.identifier.scopusid | 2-s2.0-1842474842 | * |
dc.author.google | Lee S.-H. | * |
dc.author.google | Jung J.-Y. | * |
dc.author.google | Han K.-H. | * |
dc.author.google | Yang C.-W. | * |
dc.author.google | Choi K.-B. | * |
dc.author.google | Kim J. | * |
dc.contributor.scopusid | 최규복(36096388100) | * |
dc.contributor.scopusid | 한기환(14622504200) | * |
dc.date.modifydate | 20240123095704 | * |