View : 18 Download: 0

Bacterial-modulated signaling pathways in gut homeostasis.

Title
Bacterial-modulated signaling pathways in gut homeostasis.
Authors
Lee W.J.
Ewha Authors
이원재
Issue Date
2008
Journal Title
Science signaling
ISSN
1937-9145JCR Link
Citation
vol. 1, no. 21
Indexed
SCOPUS WOS scopus
Abstract
Symbiotic mutualism with gut microbes occurs in all metazoans, and it is well established that commensal bacteria influence multiple aspects of host gut physiology such as innate immunity and development. However, our understanding of these coevolved interactions between prokaryotes and eukaryotes remains unclear. One mechanism by which commensal bacteria modulate host intracellular signaling pathways in order to avoid excess inflammation has now been determined. In this process, bacterial-induced reactive oxygen species in gut epithelial cells act as key messengers that inhibit the cullin-1-dependent protein degradation machinery, which in turn results in the stabilization of a master negative regulator of inflammation, inhibitor of nuclear factor-kappaB (IkappaB). Furthermore, this bacterial-mediated system also appears to be involved in the stabilization of a key developmental regulator, beta-catenin. These findings provide new insights into the molecular mechanisms by which commensal microbes shape host cellular physiology.
DOI
10.1126/stke.121pe24
Appears in Collections:
일반대학원 > 바이오융합과학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE