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Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hepatic dysfunction

Title
Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hepatic dysfunction
Authors
Yeom J.-S.Park S.-H.Ryu S.-H.Park H.-K.Woo S.-Y.Ha E.-H.Lee B.-E.Yoo K.Lee J.-H.Kim K.-H.Kim S.Kim Y.-A.Ahn S.-Y.Oh S.Park H.-J.Min G.-S.Seoh J.-Y.Park J.-W.
Ewha Authors
박혜경서주영하은희김광호유권이주호우소연
SCOPUS Author ID
박혜경scopus; 서주영scopus; 하은희scopus; 김광호scopus; 유권scopus; 이주호scopus; 우소연scopus
Issue Date
2003
Journal Title
Transactions of the Royal Society of Tropical Medicine and Hygiene
ISSN
0035-9203JCR Link
Citation
vol. 97, no. 6, pp. 687 - 691
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aim of this study was to compare the serum cytokine profiles of Plasmodium vivax malaria patients who presented with and without hepatic dysfunction. This is a retrospective analysis of 74 consecutive cases of P. vivax malaria seen at 3 military hospitals near the Demilitarized Zone in South Korea from 1999 to 2000. All patients studied were adult active duty servicemen. On admission, the mean (± SEM) age of the patients who presented with (n = 36) and without hepatic dysfunction (n = 38) was 21.6 ± 0.24 and 22.5 ± 0.44 years, respectively (P = 0.72). On admission, there was no significant difference between the 2 patient populations in terms of mean temperature, haemoglobin level, haematocrit, total white blood cell count, platelet count, parasite index, and serum concentration of transforming growth factor-β. Plasmodium vivax malaria patients who presented with hepatic dysfunction had significantly higher mean serum concentrations of soluble Fas ligand, interleukin (IL)-l, IL-4, IL-6, IL-10, tumor necrosis factor-α, and interferon-γ than those without hepatic dysfunction, suggesting the involvement of these cytokines in the development of hepatic dysfunction. The mean serum concentration of IL-12 was significantly lower in patients with hepatic dysfunction. The mean body temperature was not significantly different between the 2 patient populations.
DOI
10.1016/S0035-9203(03)80104-9
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의과대학 > 의학과 > Journal papers
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