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Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hepatic dysfunction

Title
Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hepatic dysfunction
Authors
Yeom J.-S.Park S.-H.Ryu S.-H.Park H.-K.Woo S.-Y.Ha E.-H.Lee B.-E.Yoo K.Lee J.-H.Kim K.-H.Kim S.Kim Y.-A.Ahn S.-Y.Oh S.Park H.-J.Min G.-S.Seoh J.-Y.Park J.-W.
Ewha Authors
박혜경서주영하은희김광호유권이주호우소연
SCOPUS Author ID
박혜경scopus; 서주영scopus; 하은희scopus; 김광호scopus; 유권scopus; 이주호scopus; 우소연scopus
Issue Date
2003
Journal Title
Transactions of the Royal Society of Tropical Medicine and Hygiene
ISSN
0035-9203JCR Link
Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene vol. 97, no. 6, pp. 687 - 691
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The aim of this study was to compare the serum cytokine profiles of Plasmodium vivax malaria patients who presented with and without hepatic dysfunction. This is a retrospective analysis of 74 consecutive cases of P. vivax malaria seen at 3 military hospitals near the Demilitarized Zone in South Korea from 1999 to 2000. All patients studied were adult active duty servicemen. On admission, the mean (± SEM) age of the patients who presented with (n = 36) and without hepatic dysfunction (n = 38) was 21.6 ± 0.24 and 22.5 ± 0.44 years, respectively (P = 0.72). On admission, there was no significant difference between the 2 patient populations in terms of mean temperature, haemoglobin level, haematocrit, total white blood cell count, platelet count, parasite index, and serum concentration of transforming growth factor-β. Plasmodium vivax malaria patients who presented with hepatic dysfunction had significantly higher mean serum concentrations of soluble Fas ligand, interleukin (IL)-l, IL-4, IL-6, IL-10, tumor necrosis factor-α, and interferon-γ than those without hepatic dysfunction, suggesting the involvement of these cytokines in the development of hepatic dysfunction. The mean serum concentration of IL-12 was significantly lower in patients with hepatic dysfunction. The mean body temperature was not significantly different between the 2 patient populations.
DOI
10.1016/S0035-9203(03)80104-9
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의과대학 > 의학과 > Journal papers
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