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Avellino corneal dystrophy after LASIK

Title
Avellino corneal dystrophy after LASIK
Authors
Jun R.M.Tchah H.Kim T.-I.Stulting R.D.Jung S.E.Seo K.Y.Lee D.H.Kim E.K.
Ewha Authors
전루민
SCOPUS Author ID
전루민scopus
Issue Date
2004
Journal Title
Ophthalmology
ISSN
0161-6420JCR Link
Citation
vol. 111, no. 3, pp. 463 - 468
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: To report cases of Avellino corneal dystrophy (ACD) exacerbated by LASIK for myopia. Design: Retrospective, noncomparative, interventional case series and review of the literature. Participants: Seven patients. Intervention: Six patients with exacerbation of granular corneal deposits after LASIK were examined for TGFBI mutations by polymerase chain reaction sequencing of DNA. One previously reported patient who was heterozygous for the ACD gene was followed up for 16 months after mechanical removal of granular deposits from the interface after LASIK. Main Outcome Measures: Slit-lamp examination, visual acuity, manifest refraction, and DNA sequencing analysis. Results: All patients were heterozygous for the Avellino dystrophy gene. Corneal opacities appeared 12 months or more after LASIK. Best spectacle-corrected visual acuity decreased as the number and density of the opacities increased. One patient underwent mechanical removal of granules from the interface and had a severe recurrence within 16 months. Another patient had removal of the granules from the interface with PTK, followed by treatment with topical mitomycin C. In this patient, the cornea has remained relatively clear for 6 months. Conclusions: Laser in situ keratomileusis increases the deposition of visually significant corneal opacities and is contraindicated in patients with ACD. Mechanical removal of the material from the interface does not prevent further visually significant deposits. Mitomycin C treatment, in conjunction with surgical removal of opacities, may be an effective treatment. © 2004 by the American Academy of Ophthalmology.
DOI
10.1016/j.ophtha.2003.06.026
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의과대학 > 의학과 > Journal papers
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