Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박진선 | * |
dc.date.accessioned | 2016-08-28T11:08:33Z | - |
dc.date.available | 2016-08-28T11:08:33Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-1760 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219354 | - |
dc.description.abstract | Tyrosine hydroxylase (TH) catalyzes the conversion of L-tyrosine to 3,4-dihydroxy-L-phenylalanine, which is the first and rate-limiting step in catecholamine biosynthesis. In the present study, we report that treatment with the histone deacetylase (HDAC) inhibitors, trichostatin A (TSA) or sodium butyrate, prominently induces the TH promoter activity in both non-neuronal and neuronal cell lines. By analyzing a series of deletional reporter constructs, we also determined that the proximal 151bp region of the TH promoter is largely responsible for TSA-mediated activation. Finally, we found that mutation of the Sp1 or CRE site, residing in the proximal area, abolishes TSA-mediated activation, strongly suggesting that the Sp1 and CRE sites may mediate TH promoter activation by inhibition of HDAC. In summary, our results provide a novel regulatory frame in which modulation of chromatin structure by histone deacetylase may contribute to transcriptional regulation of the TH via the Sp1 and/or CRE site. © 2003 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Regulation of the tyrosine hydroxylase gene promoter by histone deacetylase inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 312 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 950 | * |
dc.relation.lastpage | 957 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2003.11.012 | * |
dc.identifier.wosid | WOS:000187252300013 | * |
dc.identifier.scopusid | 2-s2.0-0344495400 | * |
dc.author.google | Kim H.-S. | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Hong S.-J. | * |
dc.author.google | Woo M.-S. | * |
dc.author.google | Kim S.-Y. | * |
dc.author.google | Kim K.-S. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박진선(54914743600) | * |
dc.date.modifydate | 20240215165648 | * |