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Chronic restraint stress massively alters the expression of genes important for lipid metabolism and detoxification in liver

Title
Chronic restraint stress massively alters the expression of genes important for lipid metabolism and detoxification in liver
Authors
Ha H.-Y.Kim K.-S.Yeom Y.I.Lee J.-K.Han P.-L.
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2003
Journal Title
Toxicology Letters
ISSN
0378-4274JCR Link
Citation
vol. 146, no. 1, pp. 49 - 63
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Repeatedly delivered psychological, chemical or physical stress leads to drastic changes of physiology in various regions of body including liver. The underlying hepatic mechanisms whereby body copes with the stress conditions, however, are poorly understood. In the present study, we performed a genome-wide screen for the altered gene expression in liver of mice that were exposed to chronic restraint stress. cDNA microarray analysis followed by RT-PCR techniques led us to identify >235 genes that were up- or down-regulated by >1.8-fold in their expression levels. Among the wide ranges of genes identified from the screen, the elevated expression of a group of genes important for lipid metabolism and detoxification were particularly notable. The results of this study suggest that similar to the effects of genetically predisposed or externally-delivered environmental chemicals, diets, and drugs, the chronic restraint stress potently alters the gene expression profile in liver. © 2003 Published by Elsevier Ireland Ltd.
DOI
10.1016/j.toxlet.2003.09.006
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일반대학원 > 뇌·인지과학과 > Journal papers
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