Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전길자 | * |
dc.contributor.author | 배윤수 | * |
dc.contributor.author | 고수영 | * |
dc.contributor.author | 한소엽 | * |
dc.contributor.author | 임진경 | * |
dc.date.accessioned | 2016-08-28T11:08:31Z | - |
dc.date.available | 2016-08-28T11:08:31Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 1015-8987 | * |
dc.identifier.other | OAK-1727 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219337 | - |
dc.description.abstract | A factor stimulating a mitogenic activity of peritoneal macrophages is purified from bovine udder. It is identified as a triglyceride, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (rac-MADG). In this study, its enantiomers, R-(+)-and S-(-)-1-palmitoyl-2-linoleoyl-3-acetylglycerol (R-(+)-MADG, S-(-)-MADG) are synthesized. Among them, R-(+)-MADG enantiomer turns out to increase a mitogenic activity in mouse peritoneal macrophages. Also, (S)-(-)-MADG shows a low mitogenic activity. Treatment of a macrophage with R-(+)-MADG increases reactive oxygen species (ROS). Furthermore, treatment of macrophages with antioxidant, N-acetyl-L-cysteine (NAC), suppresses the R-(+)-MADG-dependent macrophage proliferation. Results show that the generation of ROS induces in R-(+)-MADG-dependent cell signaling. Treatment of a macrophage with R-(+)-MADG increases the activity of protein kinase C (PKC). Treatment of macrophages with calphostin C inhibits R-(+)-MADG-induced macrophage proliferation. Results suggest that R-(+)-MADG enhances the activity of protein kinase C (PKC) and stimulates the macrophage growth. In conclusions, R-(+)-MADG accelerates the production of ROS and increases the activity of PKC to eventually stimulate macrophage cell growth. The existence of rac-MADG in bovine udder and milk provides passive protection for the neonate and immunostimulatory capabilities. Copyright © 2003 S. Karger AG, Basel. | * |
dc.language | English | * |
dc.title | Triacylglycerol, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol isolated from bovine udder and its synthetic enantiomer can potentiate the mitogenic activity for mouse peritoneal macrophages | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 415 | * |
dc.relation.lastpage | 422 | * |
dc.relation.journaltitle | Cellular Physiology and Biochemistry | * |
dc.identifier.doi | 10.1159/000075129 | * |
dc.identifier.wosid | WOS:000186684400010 | * |
dc.identifier.scopusid | 2-s2.0-0345689348 | * |
dc.author.google | Suh J.S. | * |
dc.author.google | Kwon J. | * |
dc.author.google | Eun J.S. | * |
dc.author.google | Lee Y.J. | * |
dc.author.google | Limb J.K. | * |
dc.author.google | Ko S.Y. | * |
dc.author.google | Han S.Y. | * |
dc.author.google | Bae Y.S. | * |
dc.author.google | Jhon G.J. | * |
dc.contributor.scopusid | 전길자(6701488476) | * |
dc.contributor.scopusid | 배윤수(15031067200) | * |
dc.contributor.scopusid | 고수영(7403325351) | * |
dc.contributor.scopusid | 한소엽(7405944194) | * |
dc.contributor.scopusid | 임진경(7003530407) | * |
dc.date.modifydate | 20240415133331 | * |