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Acute Lymphoblastic Leukemia Without the Philadelphia Chromosome Occurring in Chronic Myelogenous Leukemia With the Philadelphia Chromosome

Title
Acute Lymphoblastic Leukemia Without the Philadelphia Chromosome Occurring in Chronic Myelogenous Leukemia With the Philadelphia Chromosome
Authors
Huh H.J.Huh J.W.Seong C.M.Lee M.Chung W.S.
Ewha Authors
이미애정화순성주명허정원
SCOPUS Author ID
이미애scopus; 정화순scopus; 성주명scopus; 허정원scopus
Issue Date
2003
Journal Title
American Journal of Hematology
ISSN
0361-8609JCR Link
Citation
vol. 74, no. 3, pp. 218 - 220
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The blast crisis in chronic myelogenous leukemia (CML) is related to the evolution of a Philadelphia chromosome (Ph)-positive clone. Secondary chromosomal abnormalities accompanied by t(9;22) are found in 70-80% of blast crises. Here we describe a patient with Ph-positive CML, who developed Ph-negative acute lymphoblastic leukemia (ALL). A 52-year-old man was diagnosed with CML with the Ph chromosome in the chronic phase. He achieved a partial cytogenetic response after 4 months of imatinib mesylate therapy. After 8 months, common ALL occurred. At that time his karyotype was normal and the Ph chromosome was not noted. © 2003 Wiley-Liss, Inc.
DOI
10.1002/ajh.10409
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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