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Lung function in patients with chronic airflow obstruction due to tuberculous destroyed lung

Title
Lung function in patients with chronic airflow obstruction due to tuberculous destroyed lung
Authors
Lee J.H.Chang J.H.
Ewha Authors
장중현이진화
SCOPUS Author ID
장중현scopus; 이진화scopus
Issue Date
2003
Journal Title
Respiratory Medicine
ISSN
0954-6111JCR Link
Citation
vol. 97, no. 11, pp. 1237 - 1242
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Lung function in cases of chronic airflow obstruction (CAO) due to tuberculous destroyed lung, which is still common in Korea, has not been objectively investigated. We evaluated lung functions and postbronchodilator responses in 21 CAO patients with a forced expiratory volume in 1 s (FEV1) of 30-65% of the predicted value, and compared some of these resutts with those of age-,. sex- and FEV1% predicted-matched patients with chronic obstructive pulmonary disease (COPD). In addition, we analyzed the lung functions of CAO patients with respect to wheezing. The forced vital capacity (FVC) (P < 0.05) and postbronchodilator FEV1 of CAO patients were lower than those of COPD patients (P < 0.05). When a positive bronchodilator response was defined as an absolute change of FEV1 (FEV, Δabs) of more than 0.21 (P<0.05) and a percentage of initial FEV1 (FEV1 Δ%init) of more than 12%, the positive rates in CAO patients were lower than in COPD patients (P < 0.05). Among the CAO patients, patients with wheezing showed lower forced expiratory flow 25%-75% (FEF25-75%) (P < 0.05) and higher airway resistance than those without wheezing (P < 0,05). CAO patients with wheezing were more responsive to bronchodilator than those without wheezing. Although the pathophysiotogy of CAO differs from that of COPD, bronchodilator therapy could be useful for treating CAO, especially in cases presenting with wheezing. © 2003 Elsevier Ltd. All rights reserved.
DOI
10.1016/S0954-6111(03)00255-5
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의학전문대학원 > 의학과 > Journal papers
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