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Styrylheterocycles: A novel class of inhibitors on lipopolysaccharide-Induced nitric oxide production

Title
Styrylheterocycles: A novel class of inhibitors on lipopolysaccharide-Induced nitric oxide production
Authors
Lee S.K.Min H.Y.Huh S.K.Kim E.-Y.Lee E.Song S.Kim S.
Ewha Authors
이상국
Issue Date
2003
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 13, no. 21, pp. 3689 - 3692
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A series of styrylheterocycles was prepared and their inhibitory activities against nitric oxide (NO) production were evaluated in a cell culture system using lipopolysaccharide-stimulated RAW264.7 macrophage cells. Our studies have identified a new series of inhibitors on NO production, providing the basis for further development of potent inhibitors. The preliminary structure-activity relationship, to elucidate the essential structural requirements, has been described. Mechanistic studies suggest that the suppression of iNOS mRNA transcription is, at least in part, related to the inhibitory activity of styrylheterocycles. © 2003 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2003.08.013
Appears in Collections:
약학대학 > 약학과 > Journal papers
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