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Zinc reduces low-threshold Ca2+ currents of rat thalamic relay neurons

Title
Zinc reduces low-threshold Ca2+ currents of rat thalamic relay neurons
Authors
Noh J.-H.Chung J.-M.
Ewha Authors
정준모
SCOPUS Author ID
정준모scopus
Issue Date
2003
Journal Title
Neuroscience Research
ISSN
0168-0102JCR Link
Citation
vol. 47, no. 2, pp. 261 - 265
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Whole-cell voltage-clamping of thalamic relay neurons was used to examine the possibility of a Zn2+-mediated reduction of the low-threshold transient Ca2+ current (IT) of a central element in thalamocortical oscillations. We found that Zn2+ reversibly decreased IT in a concentration-dependent manner (IC50=55 μM), mainly by reducing the number of IT channels available for activation. Zn2+ did not affect the reaction kinetics, but did affect the voltage-dependence of IT channel gating. However, the apparent alterations in gating properties were not enough to account for the huge IT reduction. © 2003 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
DOI
10.1016/S0168-0102(03)00198-6
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자연과학대학 > 생명과학전공 > Journal papers
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