View : 14 Download: 0

The expression and tyrosine phosphorylation of E-cadherin/catenin adhesion complex, and focal adhesion kinase in invasive cervical carcinomas

Title
The expression and tyrosine phosphorylation of E-cadherin/catenin adhesion complex, and focal adhesion kinase in invasive cervical carcinomas
Authors
Moon H.-S.Park W.I.Choi E.-A.Chung H.-W.Kim S.-C.
Ewha Authors
김승철정혜원문혜성
SCOPUS Author ID
김승철scopus; 정혜원scopus; 문혜성scopus
Issue Date
2003
Journal Title
International Journal of Gynecological Cancer
ISSN
1048-891XJCR Link
Citation
vol. 13, no. 5, pp. 640 - 646
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The present study aimed to confirm the hypothesis that the expression and phosphorylation status of the E-cadherin/catenin adhesion complex is related to cervical carcinogenesis and cervical cancer invasion, and to investigate the expression and the tyrosine phosphorylation of focal adhesion kinase (FAK) and its relation with E-cadherin/catenin adhesion complex. The expression of E-cadherin, α- and β-catenin, and FAK were studied by a western blot analysis with 26 cervical carcinomas, nine normal cervices, and five carcinomas in situ of cervix. The tyrosine phosphorylation of α- and β-catenin and FAK were examined by an immunoprecipitation. The expressions of α- and β-catenin and E-cadherin were reduced in cervical carcinoma, and the tyrosine phosphorylation of α- and β-catenin in cervical carcinoma was higher than in normal cervix and carcinoma in situ of cervix. Tyrosine phosphorylation of FAK was elevated in cervical carcinoma although the expression of FAK was not significantly different. Moreover, α- and β-catenin were coimmunoprecipitated with FAK. We conclude that the loss of E-cadherin/catenin proteins and the tyrosine phosphorylation of E-cadherin/catenin are involved in cervical carcinogenesis and cancer invasion. Tyrosine phosphorylation of focal adhesion kinase is also related to the cervical cancer invasion. The E-cadherin/catenin complex and FAK may be related functionally and structurally.
DOI
10.1046/j.1525-1438.2003.13396.x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE