Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현국 | * |
dc.date.accessioned | 2016-08-28T11:08:28Z | - |
dc.date.available | 2016-08-28T11:08:28Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0179-1958 | * |
dc.identifier.other | OAK-1650 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219301 | - |
dc.description.abstract | Background and aims: Apoptosis regulates cell death and influences cell proliferation and therefore may play an important role in development or growth of various malignant tumors. The Bcl-2 and p53 are closely linked in the regulation of apoptosis. We investigated the prognostic significance of Bcl-2 and p53 expression in patients with gastric cancer. Patients and methods: Immunohistochemistry was used to study Bcl-2 and p53 expression in 308 consecutive patients with gastric cancer. Results: Bcl-2 expression was positive in 39 patients (12.7%) and showed a significant negative correlation with depth of invasion and lymph node metastasis. p53 expression was observed in 105 patients (34.1%) and was significantly associated with depth of invasion, lymph node metastasis, distant metastasis, and intestinal type. Patients with Bcl-2+ tumors showed a trend to better 5-year survival rate (81%) than those with Bcl-2- negative tumors (71%). The 5-year survival rate in p53 positive cases (60%) was significantly lower than that in p53-negative cases (78%). In addition, p53 expression showed a significantly poorer prognosis in both diffuse and intestinal types. In multivariate analysis restricted to patients with R0 resection p53 expression was an independent prognostic factor (relative risk: 2.063). In combined assessment of p53 and Bcl-2 expression the group with p53+/Bcl-2- tumors showed significantly worse 5-year survival (57%) than the other groups, while best survival was seen in the group with p53+/Bcl-2+ tumors (100%). Conclusion: p53 expression is an unfavorable prognostic factor in gastric cancer. Bcl-2 expression may have possible prognostic value when combined with p53 expression. | * |
dc.language | English | * |
dc.title | Prognostic significance of Bcl-2 and p53 expression in gastric cancer | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 518 | * |
dc.relation.lastpage | 525 | * |
dc.relation.journaltitle | International Journal of Colorectal Disease | * |
dc.identifier.doi | 10.1007/s00384-003-0491-2 | * |
dc.identifier.wosid | WOS:000185614300011 | * |
dc.identifier.scopusid | 2-s2.0-0142092681 | * |
dc.author.google | Lee H.K. | * |
dc.author.google | Lee H.S. | * |
dc.author.google | Yang H.-K. | * |
dc.author.google | Kim W.H. | * |
dc.author.google | Lee K.U. | * |
dc.author.google | Choe K.J. | * |
dc.author.google | Kim J.-P. | * |
dc.contributor.scopusid | 이현국(8861888600) | * |
dc.date.modifydate | 20240118164806 | * |