Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이희승 | * |
dc.date.accessioned | 2016-08-28T11:08:27Z | - |
dc.date.available | 2016-08-28T11:08:27Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0006-8993 | * |
dc.identifier.other | OAK-1611 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219289 | - |
dc.description.abstract | Kappa opioid receptor (KOR) agonists such as U-50488H and bremazocine are analgesics and diuretics. In monkeys, the selective KOR antagonist, nor-binaltorphimine (nor-BNI), produces a long-lasting antagonism of the antinociceptive effects of U-50488H but not those of bremazocine, suggesting that KOR-mediated antinociception may occur through two distinct KORs. The aim of this study was to characterize the antagonist effect of nor-BNI against the diuretic effects of U-50488H and bremazocine in monkeys. Urine outputs were collected over 3 h subsequent to i.m. administration of KOR agonists. Both U-50488H (0.032-1 mg/kg) and bremazocine (0.00032-0.01 mg/kg) dose-dependently increased urine output and the diuretic effect reached a plateau at higher doses. The maximum effect of either U-50488H or bremazocine was approximately 15 ml/kg/3 h of urine. Pretreatment with intracisternal nor-BNI 0.32 mg significantly blocked both U-50488H (0.18 mg/kg)- and bremazocine (0.0032 mg/kg)-induced diuresis for 20 weeks. However, the same dose of nor-BNI 0.32 mg given subcutaneously was not effective. These results demonstrate that central KOR mediate KOR agonist-induced diuresis in monkeys. More important, this study provides functional evidence for a homogenous population of KOR underlying KOR-mediated diuresis and illustrates a unique pharmacological profile of nor-BNI-induced ultra-long KOR antagonism in vivo. © 2003 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 982 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 38 | * |
dc.relation.lastpage | 44 | * |
dc.relation.journaltitle | Brain Research | * |
dc.identifier.doi | 10.1016/S0006-8993(03)02938-X | * |
dc.identifier.wosid | WOS:000185264900005 | * |
dc.identifier.scopusid | 2-s2.0-0142044002 | * |
dc.author.google | Ko M.C.H. | * |
dc.author.google | Willmont K.J. | * |
dc.author.google | Lee H. | * |
dc.author.google | Flory G.S. | * |
dc.author.google | Woods J.H. | * |
dc.contributor.scopusid | 이희승(57216677572) | * |
dc.date.modifydate | 20240419142459 | * |