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Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without thrombocytopenia

Title
Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without thrombocytopenia
Authors
Park J.-W.Park S.-H.Yeom J.-S.Huh A.-J.Cho Y.-K.Ahn J.-Y.Min G.-S.Song G.-Y.Kim Y.-A.Ahn S.-Y.Woo S.-Y.Lee B.-E.Ha E.-H.Han H.-S.Yoo K.Seoh J.-Y.
Ewha Authors
서주영하은희유권우소연
SCOPUS Author ID
서주영scopus; 하은희scopus; 유권scopus; 우소연scopus
Issue Date
2003
Journal Title
Annals of Tropical Medicine and Parasitology
ISSN
0003-4983JCR Link
Citation
vol. 97, no. 4, pp. 339 - 344
Indexed
SCOPUS WOS scopus
Abstract
One of the peculiar features of Plasmodium vivax malaria in South Korea is the surprisingly high frequency of thrombocytopenia. The mechanism by which this malaria-related thrombocytopenia develops and its role in the pathology, and progress of human infection with P. vivax have not yet been completely understood. In the present study, the serum cytokine profiles of cases of P. vivax malaria who presented with thrombocytopenia were compared with those of similar cases who did not have thrombocytopenia at presentation. The subjects were the 94 consecutive cases of P. vivax malaria who presented at five hospitals in South Korea (all near the Demilitarized Zone) between May 2000 and October 2002, 47 of whom had thrombocytopenia at presentation. When mean values and (S.E.) were compared, the thrombocytopenic patients were found not only to be generally older than the non-thrombocytopenic [25.3 (1.1) v. 21.3 (0.18) years; P < 0.001] but also to have presented with higher serum concentrations of aspartate aminotransferase [77.6 (16.6) v. 32.3 (7.4) U/litre; P < 0.0001], alanine aminotransferase [96.7 (19.0) v. 44.7 (12.0) U/litre; P = 0.0001], interleukin-1 [49.9 (7.4) v. 23.7 (5.1) pg/ml; P < 0.001], interleukin-6 [174.9 (26.4) v. 57.3 (14.6) pg/ml; P = 0.001], interleukin-10 [308.2 (39.6) v. 137.9 (23.1) pg/ml; P < 0.002] and transforming growth factor-β [1134.3 (387.5) v. 416.6 (183.8) pg/ml; P < 0.0001], and higher levels of parasitaemia [4345.7 (966.6) v. 1443.8 (222.7) parasites/μl; P = 0.03). The non-thrombocytopenic patients, however, had relatively high total leucocyte counts [5.8 (0.24) v. 5.4 (0.66) leucocytes/nl; P = 0.03]. The thrombocytopenia associated with P. vivax malaria in South Korea therefore appears to be associated with elevated serum concentrations of both pro- and anti-inflammatory cytokines. To define the role of each cytokine in the development of thrombocytopenia during the course of acute P. vivax malaria, further prospective studies are needed.
DOI
10.1179/000349803235002416
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의과대학 > 의학과 > Journal papers
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