Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2016-08-28T11:08:22Z | - |
dc.date.available | 2016-08-28T11:08:22Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-1513 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219236 | - |
dc.description.abstract | TNF-related weak inducer of apoptosis (TWEAK) is a member of the TNF ligand family that induces angiogenesis in vivo. The TWEAK receptor (TweakR) is a recently identified member of the TNF receptor (TNFR) superfamily and is expressed on smooth muscle cells (SMCs) and endothelial cells (ECs). In this report we identify the TNF receptor-associated factor (TRAF) family of signal transducers as important components of TweakR-mediated NF-κB activation. Coimmunoprecipitation experiments suggested potential interactions between the cytoplasmic tail of TweakR with TRAFs 1, 2, 3, and 5. Dominant negative forms of TRAF2 and TRAF5 substantially inhibited TweakR-mediated NF-κB activation, suggesting a role of TRAFs in regulating smooth muscle and endothelial cell function. Using alanine-scanning analysis, we defined a TRAF-binding motif, PIEET, in TweakR that mediates TRAF binding and NF-κB activation. Furthermore, TweakR mutations within the TRAF-binding motif abolished TweakR-stimulated SMC migration, revealing a role for TRAFs in TweakR-induced activation events. © 2003 Elsevier Science (USA). All rights reserved. | * |
dc.language | English | * |
dc.title | TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NF-κB through TNF receptor-associated factors | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 305 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 789 | * |
dc.relation.lastpage | 796 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/S0006-291X(03)00852-0 | * |
dc.identifier.wosid | WOS:000183578500002 | * |
dc.identifier.scopusid | 2-s2.0-0038242506 | * |
dc.author.google | Han S. | * |
dc.author.google | Yoon K. | * |
dc.author.google | Lee K. | * |
dc.author.google | Kim K. | * |
dc.author.google | Jang H. | * |
dc.author.google | Lee N.K. | * |
dc.author.google | Hwang K. | * |
dc.author.google | Lee S.Y. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |