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Dynamic expression of p38β MAPK in neurons and astrocytes after transient focal ischemia

Title
Dynamic expression of p38β MAPK in neurons and astrocytes after transient focal ischemia
Authors
Piao C.S.Yu Y.-M.Han P.-L.Lee J.-K.
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2003
Journal Title
Brain Research
ISSN
0006-8993JCR Link
Citation
vol. 976, no. 1, pp. 120 - 124
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Here we report the dynamically regulated expression of p38β MAPK isoform in specific subsets of cells in postischemic brain. The activity of p38β MAPK in the postischemic brain revealed biphasic induction at 30 min and 4 days after 1 h MCAO. During the early surge period, p38β MAPK was preferentially localized in the nucleus and dendrites of neurons in the future infarction area, while during the delayed surge p38β MAPK was heavily induced in reactive astrocytes in penumbra. The temporally and spatially regulated pattern of p38β MAPK expression in the postischemic brain suggests distinct roles of p38β MAPK in neuronal death and in the astrocyte activation. © 2003 Elsevier Science B.V. All rights reserved.
DOI
10.1016/S0006-8993(03)02579-4
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
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