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dc.contributor.author김형래-
dc.contributor.author정혜원-
dc.date.accessioned2017-08-28T10:35:14Z-
dc.date.available2017-08-28T10:35:14Z-
dc.date.issued2003-
dc.identifier.issn1434-5161-
dc.identifier.otherOAK-1495-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/219228-
dc.description.abstractInterleukin-6 (IL6) has many roles essential to the regulation of the immune response, hematopoiesis, and bone resorption. Three single-nucleotide polymorphisms (SNP) in the IL6 promoter region were genotyped by the single-base extension method. The frequencies of each SNP were 0.002 (IL6-597 G → A), 0.27 (IL6-572 G → C), and 0.002 (IL6-174 G → C) in a Korean population (n = 1,082). IL6-597 G → A and IL6-174 G → C were totally linked together (d2 = 1) and showed very low allele frequencies (0.002), which are common in Caucasians. On the other hand, the frequency of the IL6-572 G → C*C allele was much higher (0.27) than that in Caucasian populations (<0.07). One of the IL6 promoter SNPs, viz., IL6-572 G → C, showed significant associations with bone mineral density (BMD), i.e., the C allele was associated with increased BMD (P=0.02, co-dominant model; P=0.007, dominant model). The mean BMD was highest in homozygous C individuals (0.67 ± 0.15), lowest in homozygous G individuals (0.58 ± 0.19), and intermediate in heterozygotes (0.64 ± 0.21). In the present study, we describe a variant in the IL6 promoter region that shows positive association with higher BMD in a gene-dose-dependent manner in pre-menopausal women.-
dc.languageEnglish-
dc.titleAssociation of interleukin-6 promoter variant with bone mineral density in pre-menopausal women-
dc.typeArticle-
dc.relation.issue5-
dc.relation.volume48-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage243-
dc.relation.lastpage248-
dc.relation.journaltitleJournal of Human Genetics-
dc.identifier.doi10.1007/s10038-003-0020-8-
dc.identifier.wosidWOS:000183285900007-
dc.identifier.scopusid2-s2.0-0038647391-
dc.author.googleChung H.W.-
dc.author.googleSeo J.-S.-
dc.author.googleHur S.E.-
dc.author.googleKim H.L.-
dc.author.googleKim J.Y.-
dc.author.googleJung J.H.-
dc.author.googleKim L.H.-
dc.author.googlePark B.L.-
dc.author.googleShin H.D.-
dc.contributor.scopusid김형래(35278256500)-
dc.contributor.scopusid정혜원(56499737200)-
dc.date.modifydate20180329110130-
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의과대학 > 의학과 > Journal papers
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