Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형래 | * |
dc.contributor.author | 정혜원 | * |
dc.date.accessioned | 2016-08-28T11:08:21Z | - |
dc.date.available | 2016-08-28T11:08:21Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 1434-5161 | * |
dc.identifier.other | OAK-1495 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219228 | - |
dc.description.abstract | Interleukin-6 (IL6) has many roles essential to the regulation of the immune response, hematopoiesis, and bone resorption. Three single-nucleotide polymorphisms (SNP) in the IL6 promoter region were genotyped by the single-base extension method. The frequencies of each SNP were 0.002 (IL6-597 G → A), 0.27 (IL6-572 G → C), and 0.002 (IL6-174 G → C) in a Korean population (n = 1,082). IL6-597 G → A and IL6-174 G → C were totally linked together (d2 = 1) and showed very low allele frequencies (0.002), which are common in Caucasians. On the other hand, the frequency of the IL6-572 G → C*C allele was much higher (0.27) than that in Caucasian populations (<0.07). One of the IL6 promoter SNPs, viz., IL6-572 G → C, showed significant associations with bone mineral density (BMD), i.e., the C allele was associated with increased BMD (P=0.02, co-dominant model; P=0.007, dominant model). The mean BMD was highest in homozygous C individuals (0.67 ± 0.15), lowest in homozygous G individuals (0.58 ± 0.19), and intermediate in heterozygotes (0.64 ± 0.21). In the present study, we describe a variant in the IL6 promoter region that shows positive association with higher BMD in a gene-dose-dependent manner in pre-menopausal women. | * |
dc.language | English | * |
dc.title | Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 48 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 243 | * |
dc.relation.lastpage | 248 | * |
dc.relation.journaltitle | Journal of Human Genetics | * |
dc.identifier.doi | 10.1007/s10038-003-0020-8 | * |
dc.identifier.wosid | WOS:000183285900007 | * |
dc.identifier.scopusid | 2-s2.0-0038647391 | * |
dc.author.google | Chung H.W. | * |
dc.author.google | Seo J.-S. | * |
dc.author.google | Hur S.E. | * |
dc.author.google | Kim H.L. | * |
dc.author.google | Kim J.Y. | * |
dc.author.google | Jung J.H. | * |
dc.author.google | Kim L.H. | * |
dc.author.google | Park B.L. | * |
dc.author.google | Shin H.D. | * |
dc.contributor.scopusid | 김형래(57202558385;57219111690;57567109600) | * |
dc.contributor.scopusid | 정혜원(56499737200) | * |
dc.date.modifydate | 20240415131357 | * |