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Individualization of interferon therapy using serum hepatitis B virus DNA to reduce viral relapse in patients with chronic hepatitis B: A randomized controlled trial
- Individualization of interferon therapy using serum hepatitis B virus DNA to reduce viral relapse in patients with chronic hepatitis B: A randomized controlled trial
- Chung Y.-H.; Song B.-C.; Lee G.C.; Shin J.W.; Ryu S.H.; Jung S.A.; Yoo K.; Lee H.C.; Lee Y.S.; Suh D.J.
- Ewha Authors
- 유권; 정성애
- SCOPUS Author ID
- 유권; 정성애
- Issue Date
- Journal Title
- European Journal of Gastroenterology and Hepatology
- vol. 15, no. 5, pp. 489 - 493
- SCIE; SCOPUS
- Objective: In patients with chronic hepatitis B, viral relapse following interferon (IFN) therapy may be the result of a treatment duration that is too short to prevent hepatitis B virus (HBV) from replicating later. To reduce viral relapse in patients with chronic hepatitis B who responded to IFN, we individualized the duration of therapy according to serum HBV-DNA levels. Method: Treatment duration was prolonged to maintain negative serum HBV-DNA levels for the next 6 months in 30 patients who became HBV-DNA-negative following IFN therapy (group A). Another 35 patients were treated for only 6 months (group B). All patients had HBV-DNA as well as hepatitis B surface antigen (HBsAg) in their sera for more than 6 months and were proven histologically to have chronic hepatitis. Interferon alfa (IFN-α) was administered subcutaneously at a dose of 5 MU/m 2 three times a week. Results: There were no differences in age, gender, hepatitis B e antigen (HBeAg) positivity, serum alanine aminotransferase (ALT) levels, or serum HBV-DNA levels between the two groups. The mean duration of IFN therapy in group A was 7.2 months. At the end of treatment, serum HBV-DNA was negative in 16 patients in group A and in 18 patients in group B. The loss of serum HBV-DNA was maintained to the end of follow-up in 13 patients in group A but in only eight patients in group B. Similarly, serum ALT levels were normal in 14 patients in group A but in only nine patients in group B at the end of follow-up. Conclusion: Individualization of the duration of treatment to maintain serum HBV-DNA negativity for at least 6 months may reduce the viral relapse rate following IFN therapy. © 2003 Lippincott Williams & Wilkins.
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