View : 28 Download: 0

Individualization of interferon therapy using serum hepatitis B virus DNA to reduce viral relapse in patients with chronic hepatitis B: A randomized controlled trial

Title
Individualization of interferon therapy using serum hepatitis B virus DNA to reduce viral relapse in patients with chronic hepatitis B: A randomized controlled trial
Authors
Chung Y.-H.Song B.-C.Lee G.C.Shin J.W.Ryu S.H.Jung S.A.Yoo K.Lee H.C.Lee Y.S.Suh D.J.
Ewha Authors
유권정성애
SCOPUS Author ID
유권scopus; 정성애scopus
Issue Date
2003
Journal Title
European Journal of Gastroenterology and Hepatology
ISSN
0954-691XJCR Link
Citation
vol. 15, no. 5, pp. 489 - 493
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Objective: In patients with chronic hepatitis B, viral relapse following interferon (IFN) therapy may be the result of a treatment duration that is too short to prevent hepatitis B virus (HBV) from replicating later. To reduce viral relapse in patients with chronic hepatitis B who responded to IFN, we individualized the duration of therapy according to serum HBV-DNA levels. Method: Treatment duration was prolonged to maintain negative serum HBV-DNA levels for the next 6 months in 30 patients who became HBV-DNA-negative following IFN therapy (group A). Another 35 patients were treated for only 6 months (group B). All patients had HBV-DNA as well as hepatitis B surface antigen (HBsAg) in their sera for more than 6 months and were proven histologically to have chronic hepatitis. Interferon alfa (IFN-α) was administered subcutaneously at a dose of 5 MU/m 2 three times a week. Results: There were no differences in age, gender, hepatitis B e antigen (HBeAg) positivity, serum alanine aminotransferase (ALT) levels, or serum HBV-DNA levels between the two groups. The mean duration of IFN therapy in group A was 7.2 months. At the end of treatment, serum HBV-DNA was negative in 16 patients in group A and in 18 patients in group B. The loss of serum HBV-DNA was maintained to the end of follow-up in 13 patients in group A but in only eight patients in group B. Similarly, serum ALT levels were normal in 14 patients in group A but in only nine patients in group B at the end of follow-up. Conclusion: Individualization of the duration of treatment to maintain serum HBV-DNA negativity for at least 6 months may reduce the viral relapse rate following IFN therapy. © 2003 Lippincott Williams & Wilkins.
DOI
10.1097/00042737-200305000-00006
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE