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Autologous Stem Cell Transplantation for the Treatment of Neuroblastoma in Korea

Title
Autologous Stem Cell Transplantation for the Treatment of Neuroblastoma in Korea
Authors
Ryu K.H.Ahn H.S.Koo H.H.Kook H.Kim M.K.Kim H.K.Ghim T.Moon H.N.Seo J.J.Sung K.W.Shin H.Y.Yoo E.-S.Lyu C.J.Lee Y.H.Lee H.Cho B.Cho H.S.Choi H.S.Hah J.O.Hwang T.J.
Ewha Authors
유경하유은선
SCOPUS Author ID
유경하scopus; 유은선scopus
Issue Date
2003
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 18, no. 2, pp. 242 - 247
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Autologous stem cell transplantation (ASCT) for the treatment of high-risk neuroblastoma (NBL) is an accepted method for restoring bone marrow depression after high dose chemotherapy. We retrospectively analyzed eighty eight cases of NBL that underwent ASCT following marrow ablative therapy at 12 transplant centers of the Korean Society of Pediatric Hematology-Oncology between January 1996 and September 2000. Seventy nine children were of stage IV NBL and 9 were of stage III with N-myc amplification. Various cytoreductive regimens were used. However, the main regimen was 'CEM' consisting of carboplatin, etoposide and melphalan, and this was used in 66 patients. Total body irradiation was also added in 36 patients for myeloablation. To reduce tumor cell contamination, stem cell infusions after CD34 + cell selection were performed in 16 patients. Post-transplantation therapies included the second transplantation in 18 patients, interleukin-2 therapy in 45, 13-cis retinoic acid in 40, 131-meta-iodobenzylguanidine in 4, conventional chemotherapy in 11, and local radiotherapy in 8. Twenty two patients died, sixty six patients are surviving 1 to 46 months after ASCT (median follow-up duration, 14.5 months). Although the follow-up period was short and the number of patients small, we believe that ASCT might improve the survival rate in high-risk NBL.
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의학전문대학원 > 의학과 > Journal papers
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