View : 30 Download: 0

Reactive oxygen species activity, mucosal lipoperoxidation and glutathione in Helicobacter pylori-infected gastric mucosa

Title
Reactive oxygen species activity, mucosal lipoperoxidation and glutathione in Helicobacter pylori-infected gastric mucosa
Authors
Jung H.K.Lee K.E.Chu S.H.Yi S.Y.
Ewha Authors
이경은이선영정혜경
SCOPUS Author ID
이경은scopus; 이선영scopus; 정혜경scopus
Issue Date
2001
Journal Title
Journal of Gastroenterology and Hepatology
ISSN
0815-9319JCR Link
Citation
vol. 16, no. 12, pp. 1336 - 1340
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background and Aim: Helicobacter pylori is considered as the major pathogen in Helicobacter pylori-associated gastroduodenal disease, but the mechanism of its action has not been fully explained. This study was performed to assess the reactive oxygen species activity and the damage in Helicobacter pylori-infected gastric mucosa. Methods: Gastric biopsy specimens were obtained from 308 patients undergoing endoscopy. Gastric mucosal damage was assessed by using luminol enhanced chemiluminescence, thiobarbituric acid-reactive substance, and mucosal glutathione. Results: The chemiluminescence and thiobarbituric acid-reactive substance-equivalent levels in the mucosa of patients with Helicobacter pylori-positive gastric mucosa (43.8 ± 134.9 c.p.m./μg tissue, 157.0 ± 96.2 nmol/g tissue, respectively) were significantly higher than in those with Helicobacter pylori-negative mucosa (6.8 ± 20.3 c.p.m./μg tissue, 110.0 ± 51.6 nmol/g tissue, respectively; P = 0.000, P = 0.016, respectively). The glutathione levels in the mucosa of patients with Helicobacter pylori-positive gastric mucosa (159.3 ± 76.6 nmol/μg tissue) were significantly lower than in those with Helicobacter pylori-negative gastric mucosa (212.3 ± 134.3 nmol/μg tissue; P = 0.008). After the data were divided according to the presence of Helicobacter pylori, there were no significant differences in chemiluminescence, thiobarbituric acid-reactive substance, and glutathione among the different macroscopic findings within Helicobacter pylori-positive and -negative gastric mucosa. Conclusions: Helicobacter pylori infection plays a pathological role in many gastrointestinal diseases through excessive mucosal-reactive oxygen species production, pronounced membrane damage, and the depletion of gastric anti-oxidants. © 2001 Blackwell Science Asia Pty Ltd.
DOI
10.1046/j.1440-1746.2001.02647.x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE