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Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain

Title
Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain
Authors
Kim J.-M.Lee H.Chang N.
Ewha Authors
장남수이화영
SCOPUS Author ID
장남수scopus; 이화영scopus
Issue Date
2002
Journal Title
Journal of Nutrition
ISSN
0022-3166JCR Link
Citation
vol. 132, no. 11, pp. 3418 - 3421
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We investigated the effects of folate deprivation on plasma folate and homocysteine and its effects on cerebral microvasculature using electron microscopy. Two levels of folic acid (0 mg and 4 mg/kg diet) were fed to 6-mo-old male rats for 8 wk. Dietary folate deprivation decreased plasma folate from 353.0 ± 29.7 nmol/L to 44.2 ± 7.2 nmol/L with a concomitant increase in plasma homocysteine from 6.15 ± 0.9 μmol/L to 19.5 ± 2.7 μmol/L. Plasma folate was negatively correlated with plasma homocysteine at wk 8 (r = -0.876, P = 0.004). Electron microscopic studies of the brains of folate-deprived rats revealed cytoplasmic swelling and mitochondrial degeneration in the endothelium, perivascular amorphous fibrosis and pericytic degenerative appearance in the cerebrocortical microvascular wall. These morphologic changes might be helpful for elucidating the mechanisms underlying the cerebrovascular and neuropathology with folate deficiency.
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신산업융합대학 > 식품영양학과 > Journal papers
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