Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정혜원 | * |
dc.contributor.author | 문혜성 | * |
dc.date.accessioned | 2016-08-28T11:08:06Z | - |
dc.date.available | 2016-08-28T11:08:06Z | - |
dc.date.issued | 2002 | * |
dc.identifier.issn | 0015-0282 | * |
dc.identifier.other | OAK-1204 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219069 | - |
dc.description.abstract | Objective: To investigate expression of matrix metalloproteinase-2 (MMP-2), membranous type 1 matrix metalloproteinase (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2) in ectopic and eutopic endometrium from women with and without endometriosis throughout the menstrual cycle. Design: Molecular studies in human tissue. Setting: Reproductive immunology laboratory of a university medical center. Patient(s): Fifty-three premenopausal woman (23 with endometriosis and 30 without endometriosis) undergoing laparoscopic surgery. Endometrium and ectopic endometriosis tissue were obtained at the time of surgery. Main Outcome Measure(s): Messenger RNA and protein expression from eutopic and ectopic endometrium was analyzed by using quantitative competitive polymerase chain reaction, zymography, and Western blot assay. Result(s): Uterine endometrium from women with endometriosis expressed higher levels of MMP-2 and MT1-MMP and lower levels of TIMP-2 than did endometrium from normal women. Conclusion(s): Eutopic endometrium from patients with endometriosis may be more invasive and prone to peritoneal implantation because of greater expression of MMP-2 and MT1-MMP and lower expression of TIMP-2 messenger RNA, compared with endometrium from women without endometriosis. Thus, increased proteolytic activity may help to explain the invasive factors that result in endometriosis. © 2002 by American Society for Reproductive Medicine. | * |
dc.language | English | * |
dc.title | Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium | * |
dc.type | Conference Paper | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 78 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 787 | * |
dc.relation.lastpage | 795 | * |
dc.relation.journaltitle | Fertility and Sterility | * |
dc.identifier.doi | 10.1016/S0015-0282(02)03322-8 | * |
dc.identifier.wosid | WOS:000178567200021 | * |
dc.identifier.scopusid | 2-s2.0-0036790793 | * |
dc.author.google | Chung H.W. | * |
dc.author.google | Lee J.Y. | * |
dc.author.google | Moon H.-S. | * |
dc.author.google | Hur S.E. | * |
dc.author.google | Park M.H. | * |
dc.author.google | Wen Y. | * |
dc.author.google | Polan M.L. | * |
dc.contributor.scopusid | 정혜원(56499737200) | * |
dc.contributor.scopusid | 문혜성(14319143700) | * |
dc.date.modifydate | 20240415131357 | * |