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Stereoselective synthesis of a novel apio analogue of neplanocin A as potential S-adenosylhomocysteine hydrolase inhibitor

Title
Stereoselective synthesis of a novel apio analogue of neplanocin A as potential S-adenosylhomocysteine hydrolase inhibitor
Authors
Moon H.R.Kim H.O.Lee K.M.Chun M.W.Kim J.H.Jeong L.S.
Ewha Authors
이강만정낙신
SCOPUS Author ID
이강만scopus
Issue Date
2002
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
vol. 4, no. 20, pp. 3501 - 3503
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
(matrix presented) A total synthesis of apio-neplanocin A, which combines properties of apio nucleoside and neplanocin A and is a potencial inhibitor of S-adenosylhomocysteine hydrolase, ws accomplished starting from D-ribose via stereoselective hydroxymethylation and RCM reaction.
DOI
10.1021/ol026624m
Appears in Collections:
약학대학 > 약학과 > Journal papers
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