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Olfactory neuroblastomas: Survival rate and prognostic factor

Title
Olfactory neuroblastomas: Survival rate and prognostic factor
Authors
Hwang S.-K.Paek S.-H.Gyu Kim D.Jeon Y.-K.Chi J.G.Jung H.-W.
Ewha Authors
황승균
SCOPUS Author ID
황승균scopus
Issue Date
2002
Journal Title
Journal of Neuro-Oncology
ISSN
0167-594XJCR Link
Citation
vol. 59, no. 3, pp. 217 - 226
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Olfactory neuroblastomas are known to be rare and clinically malignant tumors. The authors analyzed the clinical features, long-term treatment outcomes, and prognostic factors related to 21 cases of olfactory neuroblastomas, treated between January 1979 and October 2000, retrospectively reviewed with medical records and radiologic findings. The mean follow-up period was 28.7 months (range 4-178). The extent of tumor was classified according to the UCLA staging system. Statistical analysis for survival was done using the Kaplan-Meier method and the log-rank test. The mean age was 27 years (13-62), the peak incidence occurred in the second decade (8/21, 38%), and the male to female ratio was 13:8. According to the UCLA staging system, there were 3 cases of T1, 5 of T2, 6 of T3, and 7 of T4. The 5-year survival rate was 21.3% and the average survival time was 28.9 months. The group (n = 14) undergoing radical surgical resection as the primary modality, registered a higher survival rate than the radiation and chemotherapy group (n = 7), with 2-year survival rates being 76.2% vs. 14.3%, respectively (p = 0.0274). The early stage (T1, T2) groups exhibited a better survival rate than the advanced (T3, T4) groups with 5-year survival rates being 38.1% vs. 9.1%, respectively (p = 0.0336). The mean recurrence free time was 7.8 months (range 1-25). From these findings we could conclude that tumor detection in the early stage, radical surgical resection as the primary treatment modality, and regular follow-up with radiologic evaluation for recurrence or metastasis, represent important factors for an improved outcome.
DOI
10.1023/A:1019937503469
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의학전문대학원 > 의학과 > Journal papers
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