Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하은희 | * |
dc.contributor.author | 박혜숙 | * |
dc.date.accessioned | 2016-08-28T11:08:01Z | - |
dc.date.available | 2016-08-28T11:08:01Z | - |
dc.date.issued | 2002 | * |
dc.identifier.issn | 1011-8934 | * |
dc.identifier.other | OAK-1105 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219016 | - |
dc.description.abstract | We investigated the influence of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms upon DNA-protein crosslinks (DPC) induced by benzo[a]pyrene (B[a]P) in cultured human lymphocytes. Lymphocyte samples were collected from 30 healthy nonsmoking hospital administrative workers. DPC was detected with KCl-SDS assay and the distributions of GSTM1 and GSTT1 were determined by polymerase chain reaction. B[a]P was found to induce a significant dose-responsive increase in cytotoxicity and DPC regardless of the genotypes (p<0.05). We did not find statistically significant genetic modification effect of GSTM1 and GSTT1 polymorphisms in the cytotoxicity and DPC formation (p>0.05). In terms of the genes examined, the level of cytotoxicity and DPC formation were found to be highest in the GSTM1-null and GSTT1-null cells. In conclusion, B[a]P induced a significant increase in the cytotoxicity and the level of DPC formation in cultured human lymphocytes. Our findings suggest that DPC could be used as a biomarker of B[a]P exposure. | * |
dc.language | English | * |
dc.title | Benzo[a]pyrene-induced DNA-protein crosslinks in cultured human lymphocytes and the role of the GSTM1 and GSTT1 genotypes. | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 17 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 316 | * |
dc.relation.lastpage | 321 | * |
dc.relation.journaltitle | Journal of Korean medical science | * |
dc.identifier.wosid | WOS:000176746100004 | * |
dc.identifier.scopusid | 2-s2.0-0036596188 | * |
dc.author.google | Park H.S. | * |
dc.author.google | Ha E.H. | * |
dc.author.google | Lee K.H. | * |
dc.author.google | Hong Y.C. | * |
dc.contributor.scopusid | 하은희(7003615774) | * |
dc.contributor.scopusid | 박혜숙(57201862679;56148186100) | * |
dc.date.modifydate | 20240419135248 | * |