View : 20 Download: 0

Doppler flow velocity measurement to assess changes in inotropy and afterload: A study in healthy dogs

Title
Doppler flow velocity measurement to assess changes in inotropy and afterload: A study in healthy dogs
Authors
Sohn S.Kim H.S.Han J.J.
Ewha Authors
한재진김혜순손세정
SCOPUS Author ID
한재진scopus; 김혜순scopus; 손세정scopus
Issue Date
2002
Journal Title
Echocardiography
ISSN
0742-2822JCR Link
Citation
vol. 19, no. 3, pp. 207 - 213
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Myocardial contractility and afterload are important factors for adequate circulation. To noninvasively assess changes in inotropy and afterload, ascending aortic blood flow was measured by continuous-wave Doppler echocardiography before and after the administration of an inotrope and a vasodilator in eight open chest dogs. Data were collected in the baseline, at three different doses of epinephrine (0.1, 0.5, and 1 μg/kg/min) and nitroprusside (1, 4, and 8 μg/kg/min) administration, and after a simultaneous infusion of both drugs in various combinations. Epinephrine infusion caused increases in peak velocity (PV), mean acceleration (MA), velocity time integral (VTI), and minute distance without a significant change in afterload. Acceleration time (AT) and ejection time (ET) showed a slight tendency to decrease with an increase in inotropy, but with no significance. Nitroprusside infusion produced dose-dependent decreases in blood pressure and index of systemic vascular resistance (ISVR), which was associated with increases in PV, MA, and minute distance, and with a decrease in AT. The combined infusion of nitroprusside and epinephrine, unless ISVR was elevated, produced synergistic effects on PV, MA, VTI, and minute distance. However, these Doppler parameters tended to diminish with an elevation in afterload. ISVR obtained during nitroprusside infusion had a better correlation with both PV and MA than with VTI or the Doppler time intervals. Our study suggests that Doppler measurement of aortic blood flow velocity and acceleration can be used for the noninvasive assessment of changes in inotropy and afterload.
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE