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Synthesis and selective tumor targeting properties of water soluble porphyrin-Pt(II) conjugates

Title
Synthesis and selective tumor targeting properties of water soluble porphyrin-Pt(II) conjugates
Authors
Song R.Kim Y.-S.Sohn Y.S.
Ewha Authors
손연수
SCOPUS Author ID
손연수scopus
Issue Date
2002
Journal Title
Journal of Inorganic Biochemistry
ISSN
0162-0134JCR Link
Citation
vol. 89, no. 1-2, pp. 83 - 88
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We have designed and synthesized a series of novel water soluble porphyrins and their platinum(II) conjugates, cis-[(Por)Pt(dmso)X], where Por=5-(4-pyridyl)-10,15,20-tris(4-sulfonatophenyl)porphyrin) (PyTPPS) or 5-[4-(3-aminopropyl)pyridiniumyl]-10,15,20-tris(4-sulphonatophenyl)porphyrin (PyTPPS-NPn), X=2Cl, 1,1-cyclobutanedicarboxylic acid, oxalate, or malonate. Their biodistribution in tumor bearing mouse was examined along with their antitumor activity against murine leukemia L1210 cell line. The representative complex 1 exhibited a significant accumulation in tumor tissue with a tumor/muscle ratio of 7 after 24 h post injection. The antitumor activity of the title compounds was marginal (T/C: 95-117%), but it was found that platinum(II) coordination to the porphyrin periphery did not affect the tumor accumulating properties of the porphyrin permitting further derivatization for efficient delivery of the Pt(II) antitumor agent. Copyright © 2001 Elsevier Science Inc.
DOI
10.1016/S0162-0134(01)00413-5
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자연과학대학 > 화학·나노과학전공 > Journal papers
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