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Genetic susceptibility of term pregnant women to oxidative damage

Title
Genetic susceptibility of term pregnant women to oxidative damage
Authors
Hong Y.-C.Lee K.-H.Yi C.-H.Ha E.-H.Christiani D.C.
Ewha Authors
하은희
SCOPUS Author ID
하은희scopus
Issue Date
2002
Journal Title
Toxicology Letters
ISSN
0378-4274JCR Link
Citation
vol. 129, no. 3, pp. 255 - 262
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Genetic polymorphisms involved in the activation and detoxification of exogenous chemicals and in the production and scavenging of reactive oxygen species may modulate the levels of oxidative injury biomarker. We investigated 81 pregnant women in Inchon, Korea. In addition to a questionnaire survey, urinary concentrations of 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA) were measured as oxidative injury biomarkers. Cytochrome P-450(CYP)1A1, CYP2E1, glutathione S-transferase (GST)M1 and GSTT1 polymorphisms and myeloperoxidase (MPO) and manganese superoxide dismutase (MnSOD) polymorphisms were evaluated to determine the effect of genetic modification on urinary 8-OH-dG and MDA. The concentrations of urinary 8-OH-dG were significantly elevated in the presence of the MnSOD variant genotype (P=0.04) and in the case of GSTM1 null status (P=0.02) by multivariate regression. The concentrations of urinary MDA were not affected significantly by the genetic polymorphisms. This result shows that oxidative stress injury is modified by some heritable polymorphisms, including GSTM1 and MnSOD. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
DOI
10.1016/S0378-4274(02)00014-0
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의과대학 > 의학과 > Journal papers
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