View : 18 Download: 0

6-Arylamino-5,8-quinazolinediones as potent inhibitors of endothelium-dependent vasorelaxation

Title
6-Arylamino-5,8-quinazolinediones as potent inhibitors of endothelium-dependent vasorelaxation
Authors
Ryu C.-K.Shin K.-H.Seo J.-H.Kim H.-J.
Ewha Authors
유충규김화정
SCOPUS Author ID
유충규scopus; 김화정scopus
Issue Date
2002
Journal Title
European Journal of Medicinal Chemistry
ISSN
0223-5234JCR Link
Citation
vol. 37, no. 1, pp. 77 - 82
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
6-(Substituted-phenyl)amino-5,8-quinazolinediones (3) were synthesised by regioselective substitution of 5,8-quinazolinedione (5) with appropriate arylamines in the presence of Ce(III) ions. All synthesised 5,8-quinazolinediones 3 showed a potent and efficacious inhibitory effect on the acetylcholine (ACh)-induced vasorelaxation of rat aorta with the endothelium. The quinones 3, at a low concentration of 0.1 μM, reduced the maximal response with increase of EC50 values for ACh. The results indicate that quinones 3 are potent inhibitors of endothelium-dependent vasorelaxation. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
DOI
10.1016/S0223-5234(01)01290-9
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE