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Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine

Title
Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine
Authors
Yun J.-S.Kim H.-S.Lee M.-K.Oh K.-W.Jang C.-G.Park W.-K.Seong Y.-H.Lee S.-C.Oh S.-K.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2001
Journal Title
Pharmacological Research
ISSN
1043-6618JCR Link
Citation
vol. 44, no. 6, pp. 473 - 479
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A single high dose of apomorphine (10 mg kg -1) produced not only contextual sensitization to and conditioning of climbing behavior, but also context-independent tolerance to hypothermia. MK-801 (0.15 and 0.3 mg kg -1) inhibited contextual sensitization to and conditioning of climbing behavior. Development of tolerance to hypothermia was also inhibited by MK-801. Dopamine D1 antagonist, SCH23390 (0.5 mg kg -1), but not D2 antagonist, sulpiride, inhibited sensitization to and conditioning of climbing behavior. D2 antagonist, sulpiride (50 mg kg -1), but not D1 antagonist, SCH23390, inhibited development of tolerance to hypothermia. These results suggest that MK-801 inhibited contextual sensitization to climbing behavior and development of tolerance to hypothermia through glutamatergic modulation of dopaminergic functions at dopamine receptors. © 2001 Academic Press.
DOI
10.1006/phrs.2001.0889
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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