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Radioisotope carrying polyethylene oxide - Polycaprolactone copolymer micelles for targetable bone imaging

Title
Radioisotope carrying polyethylene oxide - Polycaprolactone copolymer micelles for targetable bone imaging
Authors
Park Y.J.Lee J.Y.Chang Y.S.Jeong J.M.Chung J.K.Lee M.C.Park K.B.Lee S.J.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2002
Journal Title
Biomaterials
ISSN
0142-9612JCR Link
Citation
vol. 23, no. 3, pp. 873 - 879
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aim of this research is to develop polymeric micelle system as a targetable bone imaging carriers without nonspecific phagocytosis which is made of polyethylene oxide (PEO) and polycaprolactone (PCL). Diamino-PEO, which has two amino groups in its structure, was used to conjugate both PCL and ligand for specific radioisotope. PCL was conjugated to one amino group of diamino-PEO by using diaminohexyl cyclocarbodiimide (DCC), coupling agent. Hydroxyphenylpropionic acid (HPP), diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyl glycine glycidyl glycine (MAG3), as ligands for specific radioisotopes, were coupled to the rest of amino group of diamino-PEO by the same method as described. Formation of ligand-conjugated block copolymers, critical micelle concentration (CMC) of the copolymers, hydrodynamic radii, and morphology of the micelles were investigated. Besides, 125I-labelling efficiency and biodistribution of the micelles were examined. PEO-PCL block copolymer micelles demonstrated CMC of 25mg/l and size of 60nm, which may be adequate for blood vessel and bone imaging. 125I-labelling efficiency was above 90% and was more stable at human serum for 24h. 125I-labelled polymeric micelles showed higher blood maintenance and bone uptake when compared to stannous colloid, used as a control. A noticeable decrease in liver or spleen uptake could be achieved by the micelles. Therefore, radioisotope carrying PEO-PCL micelle system was suggested as a useful tool for effective diagnostic bone targeting and imaging. © 2001 Elsevier Science Ltd. All rights reserved.
DOI
10.1016/S0142-9612(01)00196-X
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약학대학 > 약학과 > Journal papers
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